Central wedge resection and asymmetric Z-plasty for minor labia reduction / 中华整形外科杂志

<p><b>OBJECTIVE</b>To investigate the therapeutic effect of central wedge resection and asymmetric Z-plasty for minor labia reduction.</p><p><b>METHODS</b>Based on the Giraldo procedure, the incision was designed and the redudent tissue was resected quantitatively. The Z-plasty was modified to rectangle flap with deviated incision. The incisions at the two surface of minor labia were designed in an opposited direction. The two rectangle flaps were inserted to form the free edge of minor labia.</p><p><b>RESULTS</b>11 cases of minor labia hypertrophy were treated with good results.</p><p><b>CONCLUSIONS</b>The modified procedure is easily performed with precise design. It is suitable for all kinds of minor labia hypertrophy.</p>

Treatment of complicated cavernous venous malformation with retained copper wires combined with pingyangmycin injection / 中华整形外科杂志

<p><b>OBJECTIVE</b>To evaluate the therapeutic effect of retained copper wires combined with pingyangmycin (PYM) injection for complicated cavernous venous malformation.</p><p><b>METHODS</b>The location of venous malformation was detected by physical examination and MRI. The copper wires in 0.2 mm width were used to puncture the lesion repeatedly and retained in the lesion to form a net. After that, 8 mg PYM was injected into the residue malformed veins. 8-10 days later, the copper wires were taken out and necrotic tissue was squeezed out. The wounds of punctual holes healed through dressing. The patients received postoperative MRI to evaluate the therapeutic effect.</p><p><b>RESULTS</b>From Jan. 2002 to Dec. 2008, 45 cases were treated. The patients were followed up for 1-3 years. 51.1% (23/45) of the lesions shrinked markedly or even disappeared. 42.2% (19/45) of the lesions reduced. 6.67% (3/45) of the lesions didn't change. There was no complication like invasive infection.</p><p><b>CONCLUSIONS</b>It is very effective to treat complicated cavernous venous malformation with retained copper wires combined with pingyangmycin injection.</p>

The expression and role of glucose transporter-1 in infantile hemangioma / 中华整形外科杂志

<p><b>OBJECTIVE</b>To investigate the expression and role of glucose transporter-1 (Glut1) in infantile hemangioma.</p><p><b>METHODS</b>Fifty-two samples from infantile hemangioma, 25 in cavernous venous malformation, 9 in arteriovenous malformation, 2 in capillary malformation and 5 in normal skin samples were involved in this study. The EnVision immunohistochemical stain was used to investigate the expression of Glut1 protein in these samples.</p><p><b>RESULTS</b>In the early proliferating stage, a number of endothelial cells expressed Glut1. In the middle proliferating stage, most of vascular endothelial cells and scattered endothelial cells expressed Glut1. In the late proliferating stage, the expression of Glut1 decreased quickly. In the involuting stage, all hemangioma samples didn't express Glut1. All of the samples from the cavernous venous malformations, arteriovenous malformations, capillary malformations and normal skin had no expression of Glut1.</p><p><b>CONCLUSIONS</b>Glut1 may be one of the phenotypes of infantile hemangioma endothelial cells in their development, rather than the inherent character. The expression of Glut1 changes according to the metabolic need of infantile hemangioma cells.</p>

Plastic treatment of Paget's disease of the scrotum and penis / 中华男科学杂志

<p><b>OBJECTIVE</b>To explore the clinical features and plastic treatment of Paget's disease of the scrotum and penis.</p><p><b>METHODS</b>We analyzed 11 cases of Paget's disease of the scrotum and penis treated from 1997 to 2007. Extended excision of the focus of infection was performed and the skin absence was repaired by free skin grafting, local random skin flap, and island skin flap.</p><p><b>RESULTS</b>Satisfactory wound healing was achieved in all but 1 case, which was delayed due to infection. All the patients were followed up for 1-4 years. One patient relapsed 2 years after the surgery and received a second operation, and another 1 died of lymphoma complicated by lung infection. The original shape and contractibility of the scrotum and penis were basically preserved and their appearance and function were fairly good.</p><p><b>CONCLUSION</b>For patients with Pagets disease of the scrotum and penis, it is a desirable method to at once excise the lesion and repair the skin absence by plastic surgery.</p>

Allograft transplantation with compound tissue of two ears and skin of head and neck: A report of 1 case, China / 中华整形外科杂志

<p><b>OBJECTIVE</b>To investigate the possibility and efficacy of allograft transplantation in treating patient with huge tissue defect after radical giant malignant melanoma resection.</p><p><b>METHODS</b>A male person received blood type matching was chosen as donor. Immediately after the donor's brain death, allograft was excised with the depth to the layer intervenient between periosteum and epicranial fascia in calvaria, the superficial layer of deep temporal fascia in both sides of temporal regions, close to zygomatic bones and mandibles including masseter and auricles upon in face, and cervical soft tissues including sternocleidomastoid muscles, cervical and external jugular vessels of both sides were excised simultaneously. After being perfused with 4 degrees C UW solution through both common carotid arteries, the homograft was sheared and radiated with X-ray before being preserved in UW solution for further use. During the operation, both sides of external auditory meatus were anastomosed with ears firstly, and vessels were anastomosed end-to-end sequently, at last, the border of skin flap was sutured intermittently. Combined use of MMF, FK506, Prednisone and Zenopax was performed as post-operation immunosuppressive treatment. Clinical observations were made on the signs and symptoms of graft survival or rejection as well as blood FK506 concentrations and immunological indexes were tested in laboratory. Biopsies of graft were also made at 1 h, 4 h, 8 h, 7 d, 14 d and 30 d after operation.</p><p><b>RESULTS</b>The circulation of the graft was satisfactory, and the temperature and color of skin were normal. Primary healing of suture and hair growth about 0.8 cm in a month were observed. Skin Biopsies of every time had no found of hyperacute or acute rejection. The concentration of FK506 was maintained 20 mg/ml 1 month after the operation.</p><p><b>CONCLUSION</b>Allograft transplantation with compound tissue of head skin flap and ears is a kind of effective and safe treatment in repairing huge tissue defect. Good tissue matching and combined use of currently available immunosuppressants can prevent hyperacute and acute rejection efficiently.</p>